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CCR7 (C-C chemokine receptor type 7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Diffuse large B-cell lymphoma.
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS.
In plain words · CCR7 (C-C chemokine receptor type 7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Diffuse large B-cell lymphoma.
CCR7 (C-C chemokine receptor type 7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Diffuse large B-cell lymphoma.
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
No product in this corpus aims at CCR7 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1993. Earliest sequence paper UniProt cites for the protein: Birkenbach M.P. et al, J. Virol, 1993, "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors". Source.
Sources: HGNC HGNC:1608 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P32248 (protein name, function text, keywords and locations (REST API)); IntOGen CCR7 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Location: Cell membrane (UniProt). Locus 17q21.2 (HGNC).
Query for this target: (TITLE:"CCR7" OR ABSTRACT:"CCR7" OR TITLE:"C-C motif chemokine receptor 7" OR ABSTRACT:"C-C motif chemokine receptor 7" OR TITLE:"C-C chemokine receptor type 7" OR ABSTRACT:"C-C chemokine receptor type 7" OR TITLE:"BLR2" OR ABSTRACT:"BLR2" OR TITLE:"CDw197" OR ABSTRACT:"CDw197" OR TITLE:"CD197" OR ABSTRACT:"CD197") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCR7, not a curated reading list.