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CASZ1 (Zinc finger protein castor homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Prostate Adenocarcinoma.
In plain words · CASZ1 (Zinc finger protein castor homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
CASZ1 (Zinc finger protein castor homolog 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
No product in this corpus aims at CASZ1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:26002 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86V15 (protein name, function text, keywords and locations (REST API)); IntOGen CASZ1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. Location: Nucleus (UniProt). Locus 1p36.22 (HGNC).
Query for this target: (TITLE:"CASZ1" OR ABSTRACT:"CASZ1" OR TITLE:"castor zinc finger 1" OR ABSTRACT:"castor zinc finger 1" OR TITLE:"Zinc finger protein castor homolog 1" OR ABSTRACT:"Zinc finger protein castor homolog 1" OR TITLE:"FLJ20321" OR ABSTRACT:"FLJ20321" OR TITLE:"ZNF693" OR ABSTRACT:"ZNF693" OR TITLE:"castor" OR ABSTRACT:"castor") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CASZ1, not a curated reading list.