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CADM2 (Cell adhesion molecule 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organisation, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Melanoma.
In plain words · CADM2 (Cell adhesion molecule 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
CADM2 (Cell adhesion molecule 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organisation, providing regulated trans-synaptic adhesion.
No product in this corpus aims at CADM2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2002. Earliest sequence paper UniProt cites for the protein: Gingrich J.R. et al, 2002. Source.
Sources: HGNC HGNC:29849 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8N3J6 (protein name, function text, keywords and locations (REST API)); IntOGen CADM2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organisation, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus. Location: Cell membrane; Synapse; Cell projection, axon (UniProt). Locus 3p12.1 (HGNC).
Query for this target: (TITLE:"CADM2" OR ABSTRACT:"CADM2" OR TITLE:"cell adhesion molecule 2" OR ABSTRACT:"cell adhesion molecule 2" OR TITLE:"Cell adhesion molecule 2" OR ABSTRACT:"Cell adhesion molecule 2" OR TITLE:"NECL3" OR ABSTRACT:"NECL3" OR TITLE:"Necl-3" OR ABSTRACT:"Necl-3" OR TITLE:"SynCAM2" OR ABSTRACT:"SynCAM2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CADM2, not a curated reading list.