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BMP6 (Bone morphogenetic protein 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for haemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.
In plain words · BMP6 (Bone morphogenetic protein 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
BMP6 (Bone morphogenetic protein 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation.
No product in this corpus aims at BMP6 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1990. Earliest sequence paper UniProt cites for the protein: Celeste A.J. et al, Proc. Natl. Acad. Sci. U.S.A, 1990, "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Source.
Sources: HGNC HGNC:1073 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P22004 (protein name, function text, keywords and locations (REST API)); IntOGen BMP6 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for haemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signalling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signalling cascade to modulate VEGF signalling by regulating VEGFR2 expression. Location: Secreted (UniProt). Locus 6p24.3 (HGNC).
Query for this target: (TITLE:"BMP6" OR ABSTRACT:"BMP6" OR TITLE:"bone morphogenetic protein 6" OR ABSTRACT:"bone morphogenetic protein 6" OR TITLE:"Bone morphogenetic protein 6" OR ABSTRACT:"Bone morphogenetic protein 6" OR TITLE:"VGR1" OR ABSTRACT:"VGR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BMP6, not a curated reading list.