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AJUBA (LIM domain-containing protein ajuba) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organisation, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Head and Neck Squamous Cell Carcinoma.
In plain words · AJUBA (LIM domain-containing protein ajuba) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.
AJUBA (LIM domain-containing protein ajuba) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organisation, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration.
No product in this corpus aims at AJUBA yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2003. Earliest sequence paper UniProt cites for the protein: Hirota et al, Cell, 2003, "Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells". Source.
Sources: HGNC HGNC:20250 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96IF1 (protein name, function text, keywords and locations (REST API)); IntOGen AJUBA (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organisation, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signalling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signalling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Location: Cytoplasm, cytoskeleton; Cell membrane; Cell junction; Nucleus (UniProt). Locus 14q11.2 (HGNC).
Query for this target: (TITLE:"AJUBA" OR ABSTRACT:"AJUBA" OR TITLE:"ajuba LIM protein" OR ABSTRACT:"ajuba LIM protein" OR TITLE:"LIM domain-containing protein ajuba" OR ABSTRACT:"LIM domain-containing protein ajuba" OR TITLE:"MGC15563" OR ABSTRACT:"MGC15563") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AJUBA, not a curated reading list.