Cancers & treatments·Regimen libraryCurative

COPDAC (cyclophosphamide, vincristine, prednisone, dacarbazine)

Checked 2026-09-09

Consolidation after OEPA in intermediate- and advanced-stage childhood Hodgkin lymphoma; COPP (procarbazine in place of dacarbazine) is the older version

Also called COPDAC, COPP.

One cycle

every 28 days × 2-4 · about 8 weeks in total

28-day cycle × 2-4 (about 8 weeks)IntravenousOral Daily oral course

Components

Drug	Dose	Route	Days
Cyclophosphamide Alkylating agent (oxazaphosphorine prodrug)	500 mg/m²	IV	D1, 8
Vincristine Vinca alkaloid (microtubule inhibitor)	1.5 mg/m² (maximum 2 mg)	IV	D1, 8
Prednisone Glucocorticoid	40 mg/m² once daily	Oral	D1-15
Dacarbazine Alkylating agent (triazene)	250 mg/m²	IV	D1-3

Cycles

2-4

28-day cycle

Emetogenicity

High (>90%)

G-CSF

Not routine

Notes

Dacarbazine replaced procarbazine to avoid infertility in boys, with the same event-free survival.
EuroNet-PHL-C2 tested intensified COPDAC-28 to reduce the need for radiotherapy.

Used in

Hodgkin lymphoma

Products

CyclophosphamideVincristinePrednisoneDacarbazine

Source

Mauz-Körholz (GPOH-HD-2002), JCO 2010: procarbazine-free OEPA-COPDAC in boys and OPPA-COPP in girls

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.