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In one of the most lethal cancers known, dabrafenib plus trametinib shrank BRAF-mutant anaplastic thyroid cancer in about two thirds of patients, leading to the first ever drug approval for the disease.
Anaplastic thyroid cancer cohort of the phase 2 ROAR basket trial: 16 patients with BRAF V600E-mutant locally advanced or metastatic anaplastic thyroid cancer treated with dabrafenib plus trametinib.
Objective response was 69 percent with responses lasting more than a year in most, twelve-month overall survival of about 80 percent in an updated analysis, and manageable toxicity; the approval followed in 2018.
Rapid BRAF testing is mandatory at diagnosis of anaplastic thyroid cancer, and BRAF-MEK inhibition, increasingly with pembrolizumab and as neoadjuvant therapy, is the standard for BRAF-mutant disease.
Shares Dabrafenib, Trametinib, Journal of Clinical Oncology.
Shares Dabrafenib, Trametinib.
Shares Dabrafenib, Trametinib.
Shares Dabrafenib, Trametinib.
Shares Dabrafenib, Trametinib.
Shares Dabrafenib, Trametinib.
Shares Dabrafenib, Trametinib, Journal of Clinical Oncology.
Shares Dabrafenib, Trametinib.