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This series defined myxofibrosarcoma as a distinct sarcoma of elderly limbs with characteristic curvilinear blood vessels and a strong tendency to recur locally and progress in grade, features that still guide its wide excision.
Clinicopathological study of 75 cases of myxofibrosarcoma establishing diagnostic criteria (multinodular growth, myxoid stroma, curvilinear vessels, pleomorphic cells), a grading spectrum from low to high grade, a local recurrence rate of about 50 to 60 percent often with grade progression, and metastasis mainly from high-grade tumours.
The recognition that myxofibrosarcoma infiltrates along tissue planes far beyond the visible mass underlies the wide, MRI-planned excision and adjuvant radiotherapy recommended today.