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The reference description of acinar cell carcinoma, the rare pancreatic cancer that grows from enzyme-producing cells: how it looks under the microscope, how to prove it with enzyme stains, and how it behaves, which is aggressive but somewhat less so than ordinary pancreatic cancer.
Clinicopathological study of 28 acinar cell carcinomas from the Armed Forces Institute of Pathology and Memorial Sloan Kettering. The tumours were large, mostly in older men, and about half had metastasised at diagnosis; a minority presented with the lipase hypersecretion syndrome of subcutaneous fat necrosis and polyarthralgia.
Histologically the tumours showed acinar and solid growth with minimal stroma, and immunohistochemistry for trypsin, chymotrypsin and lipase confirmed acinar differentiation. Median survival was about 18 months, better than ductal adenocarcinoma but still poor, with occasional long-term survivors after resection.
This series defined the diagnostic criteria still used for acinar cell carcinoma and established that it should be classified and treated as a distinct disease from ductal adenocarcinoma.
Shares Pancreatic acinar cell carcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic acinar cell carcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic acinar cell carcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic acinar cell carcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic acinar cell carcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic acinar cell carcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic acinar cell carcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic acinar cell carcinoma, Pancreatic ductal adenocarcinoma.