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The International Myeloma Working Group lowered the threshold for diagnosing plasma cell leukaemia from 20 percent to 5 percent circulating plasma cells, because patients at 5 percent already have the same short survival.
Consensus statement from the International Myeloma Working Group reviewing evidence that 5 percent or more circulating plasma cells on a blood film carries the same short survival as the historical 20 percent threshold, and redefining primary plasma cell leukaemia accordingly, with recommendations for work-up.
More patients now receive the diagnosis and the intensive, transplant-based approach that goes with it; trial eligibility uses the new definition.