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Across ten US centres, people whose second operation for a chance-found gallbladder cancer happened four to eight weeks after the first lived longest; rushing back in under four weeks, or waiting beyond eight, went with shorter survival.
Cohort of 207 patients with incidentally discovered gallbladder cancer (46 percent of 449 gallbladder cancers) who underwent reoperation at 10 US academic institutions between 2000 and 2014, grouped by interval from cholecystectomy: under 4 weeks (25 patients, 12 percent), 4 to 8 weeks (91, 44 percent) and over 8 weeks (91, 44 percent). Groups were similar in demographics, extent of resection, residual disease, T stage, margins, nodes and complications. Median overall survival was 17.4, 40.4 and 22.4 months (log-rank p=0.03). On multivariable analysis the early (hazard ratio 2.63, 95 percent CI 1.25 to 5.54) and late (2.07, 1.17 to 3.66) intervals, R2 resection (2.69) and advanced T stage (1.85) remained associated with death.
The origin of the widely quoted four-to-eight-week window for re-resection. A 2026 individual patient data meta-analysis found no survival difference by timing, so the window is a reasonable planning target rather than a proven rule.
Shares A national incidental gallbladder cancer pathway: histology for every gallbladder, referral within two weeks, re-resection by eight, Incidental gallbladder cancer (found after cholecystectomy), Radical (extended) cholecystectomy, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials and the tag gallbladder-evidence.
Shares Incidental gallbladder cancer (found after cholecystectomy), Radical (extended) cholecystectomy, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares A national incidental gallbladder cancer pathway: histology for every gallbladder, referral within two weeks, re-resection by eight, Incidental gallbladder cancer (found after cholecystectomy), Gallbladder cancer and the tag gallbladder-evidence.
Shares A national incidental gallbladder cancer pathway: histology for every gallbladder, referral within two weeks, re-resection by eight, Incidental gallbladder cancer (found after cholecystectomy), Radical (extended) cholecystectomy, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials and the tag gallbladder-evidence.
Shares Incidental gallbladder cancer (found after cholecystectomy), Radical (extended) cholecystectomy, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Incidental gallbladder cancer (found after cholecystectomy), Radical (extended) cholecystectomy, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Incidental gallbladder cancer (found after cholecystectomy), Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
Shares Incidental gallbladder cancer (found after cholecystectomy), Radical (extended) cholecystectomy, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.