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Entrectinib, a TRK and ROS1 inhibitor that enters the brain, shrank tumours in more than half of patients with NTRK fusion-positive cancers of ten types and controlled brain metastases, leading to a tumour-agnostic approval alongside larotrectinib.
Integrated analysis of 54 adults with NTRK fusion-positive solid tumours from the ALKA-372-001, STARTRK-1 and STARTRK-2 trials treated with entrectinib.
Objective response was 57 percent with a median duration of response of 10 months and intracranial response in half of the patients with brain metastases; toxicity included weight gain, dizziness and dysgeusia.
Entrectinib is an approved tumour-agnostic TRK inhibitor with an advantage in patients with brain metastases, and it is also approved for ROS1-positive lung cancer.
Shares Entrectinib, The Lancet Oncology.
Shares NTRK fusion-positive non-small-cell lung cancer, Entrectinib.
Shares Robert C. Doebele, NTRK fusion-positive non-small-cell lung cancer, Entrectinib.
Shares NTRK fusion-positive non-small-cell lung cancer, Entrectinib.