Loading
Gene expression profiling identified a group of childhood leukaemias that look like Philadelphia-positive disease without the fusion gene, later called Ph-like or BCR-ABL1-like ALL, with a high relapse rate and frequent IKZF1 deletions.
Genome-wide expression classification of 190 childhood B-ALL cases identifying a novel subtype in about 15 percent of B-other cases with a signature resembling BCR-ABL1-positive ALL, frequent IKZF1 deletions, and poor five-year disease-free survival (about 60 percent) validated in independent cohorts.
This discovery, made simultaneously with the American Children's Oncology Group finding, created the Ph-like ALL category now screened for in high-risk protocols.