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In patients whose locally advanced basal cell carcinoma had progressed on or could not tolerate a hedgehog inhibitor, cemiplimab shrank tumours in about three in ten, giving a second-line option where none existed.
Phase 2 study of 84 patients with locally advanced basal cell carcinoma after progression on or intolerance of hedgehog pathway inhibitors treated with cemiplimab.
Objective response was 31 percent (6 percent complete), with an estimated 85 percent of responses lasting at least a year and toxicity typical of PD-1 blockade; the metastatic cohort responded in about a fifth.
Cemiplimab is approved for advanced basal cell carcinoma after hedgehog inhibitor therapy, adding immunotherapy to the pathway for this common but rarely advanced skin cancer.
Shares Locally advanced and metastatic basal cell carcinoma, The Lancet Oncology.
Shares Cemiplimab in basal cell carcinoma after a hedgehog inhibitor, Locally advanced and metastatic basal cell carcinoma, Cemiplimab.
Shares Cemiplimab in basal cell carcinoma after a hedgehog inhibitor, Locally advanced and metastatic basal cell carcinoma.
Shares Cemiplimab in basal cell carcinoma after a hedgehog inhibitor, Locally advanced and metastatic basal cell carcinoma.
Shares Cemiplimab in basal cell carcinoma after a hedgehog inhibitor, Locally advanced and metastatic basal cell carcinoma.
Shares Cemiplimab in basal cell carcinoma after a hedgehog inhibitor, Locally advanced and metastatic basal cell carcinoma.
Shares Locally advanced and metastatic basal cell carcinoma, Cemiplimab.
Shares Alexander J. Stratigos, Locally advanced and metastatic basal cell carcinoma, Cemiplimab.