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In the first randomised US trial of neoadjuvant treatment for borderline resectable pancreatic cancer, eight cycles of modified FOLFIRINOX alone gave two-thirds of patients an 18-month survival, while replacing the last cycle with short-course radiotherapy did worse and that arm was stopped early.
Multicentre randomised phase 2 trial in 126 patients with borderline resectable pancreatic ductal adenocarcinoma, assigned to eight cycles of modified FOLFIRINOX or to seven cycles followed by stereotactic body radiotherapy or hypofractionated image-guided radiotherapy, then surgery and adjuvant FOLFOX. The radiotherapy arm was closed at a planned interim analysis for futility.
Eighteen-month overall survival was 66.7 percent with chemotherapy alone and 47.3 percent with chemotherapy and radiotherapy; median overall survival was 29.8 against 17.1 months. The chemotherapy-alone arm met its prespecified benchmark against historical controls.
Neoadjuvant modified FOLFIRINOX without routine radiotherapy became the reference approach for borderline resectable disease in North America; radiotherapy is reserved for selected patients or trials.
Shares Chemotherapy before surgery for every resectable pancreatic cancer, settled by the two perioperative trials rather than assumed, FOLFIRINOX / mFOLFIRINOX, Pancreatic cancer roadmap: from Whipple's operation to gemcitabine, FOLFIRINOX, adjuvant chemotherapy, PARP inhibition, KRAS inhibition, vaccines and the surveillance question, Pancreatic ductal adenocarcinoma.
Shares FOLFIRINOX / mFOLFIRINOX, Borderline resectable pancreatic ductal adenocarcinoma, Pancreatic cancer roadmap: from Whipple's operation to gemcitabine, FOLFIRINOX, adjuvant chemotherapy, PARP inhibition, KRAS inhibition, vaccines and the surveillance question, Pancreatic ductal adenocarcinoma.
Shares Chemotherapy before surgery for every resectable pancreatic cancer, settled by the two perioperative trials rather than assumed, FOLFIRINOX / mFOLFIRINOX, Borderline resectable pancreatic ductal adenocarcinoma, Pancreatic cancer roadmap: from Whipple's operation to gemcitabine, FOLFIRINOX, adjuvant chemotherapy, PARP inhibition, KRAS inhibition, vaccines and the surveillance question.
Shares Chemotherapy before surgery for every resectable pancreatic cancer, settled by the two perioperative trials rather than assumed, JAMA Oncology, FOLFIRINOX / mFOLFIRINOX, Pancreatic cancer roadmap: from Whipple's operation to gemcitabine, FOLFIRINOX, adjuvant chemotherapy, PARP inhibition, KRAS inhibition, vaccines and the surveillance question.
Shares Chemotherapy before surgery for every resectable pancreatic cancer, settled by the two perioperative trials rather than assumed, FOLFIRINOX / mFOLFIRINOX, Borderline resectable pancreatic ductal adenocarcinoma, Pancreatic cancer roadmap: from Whipple's operation to gemcitabine, FOLFIRINOX, adjuvant chemotherapy, PARP inhibition, KRAS inhibition, vaccines and the surveillance question.
Shares Borderline resectable pancreatic ductal adenocarcinoma, Pancreatic cancer roadmap: from Whipple's operation to gemcitabine, FOLFIRINOX, adjuvant chemotherapy, PARP inhibition, KRAS inhibition, vaccines and the surveillance question, Pancreatic ductal adenocarcinoma.
Shares Borderline resectable pancreatic ductal adenocarcinoma, Pancreatic ductal adenocarcinoma.
Shares FOLFIRINOX / mFOLFIRINOX, Borderline resectable pancreatic ductal adenocarcinoma.