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In 131 German gallbladder cancers about one in seven had PD-L1 on tumour cells and fewer than one in twenty had a lot; high PD-L1 marked poorly differentiated tumours and shorter survival, and a second checkpoint, TIGIT, was present in some.
PD-L1 was assessed immunohistochemically in 131 gallbladder cancer patients as tumour proportion score (TPS), immune cell score and combined positive score. Tumour cells expressed PD-L1 in 14.7% of patients at a TPS cut-off of 1%; TPS above 10% and 25% was reached in 4.7% and 3.1%. At the 10% cut-off, TPS was associated with distinct histomorphological subtypes and poor differentiation.
Survival analysis showed a TPS above 10% to be a highly significant and independent negative prognosticator. PD-L1 expression was associated with increased CD4-positive, CD8-positive and PD-1-positive immune cell densities. In 14.8% of cases scattered immune cells expressed TIGIT, correlated with tumour expression of its ligand CD155.
The Western counterpart to the Indian series, with lower rates and a prognostic signal in the opposite direction from what immunotherapy enthusiasts might hope. The TIGIT and CD155 finding names a second checkpoint for future trials.
Shares PD-L1 TPS (tumour proportion score), Tumour-infiltrating lymphocytes (TILs), Immunohistochemistry (IHC), PD-L1.
Shares PD-L1 TPS (tumour proportion score), Tumour-infiltrating lymphocytes (TILs), Immunohistochemistry (IHC), PD-L1.
Shares PD-L1 CPS (combined positive score), Tumour-infiltrating lymphocytes (TILs), Immunohistochemistry (IHC), PD-L1.
Shares PD-L1 TPS (tumour proportion score), PD-L1 CPS (combined positive score), Tumour-infiltrating lymphocytes (TILs), Immunohistochemistry (IHC).
Shares PD-L1 TPS (tumour proportion score), Immunohistochemistry (IHC), PD-L1.
Shares PD-L1 TPS (tumour proportion score), Immunohistochemistry (IHC), PD-L1.
Shares PD-L1 TPS (tumour proportion score), Immunohistochemistry (IHC), PD-L1.
Shares PD-L1 TPS (tumour proportion score), PD-L1 CPS (combined positive score), Immunohistochemistry (IHC), PD-L1.