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How a tissue sample is handled before it reaches the lab changes the results of biomarker tests. That handling time is almost never recorded, so nobody can tell a true negative from a spoiled sample.
Cold ischaemia time and fixation duration affect phosphoprotein, RNA and even some IHC markers (including HER2 and ER), yet pre-analytical variables are rarely recorded in structured form. Guidelines (ASCO/CAP for HER2) specify limits but compliance is unmeasured. Adding mandatory structured fields for time to fixation and fixation duration to pathology reporting standards and laboratory information systems would let biomarker results be interpreted, audited and used in research.
Shares Publish each laboratory's biomarker proficiency results, Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue, Histopathology & immunohistochemistry, Biomarkers are not validated or standardised.
Shares Publish each laboratory's biomarker proficiency results, Immunohistochemistry (IHC), Histopathology & immunohistochemistry, Biomarkers are not validated or standardised.
Shares Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue, Biomarkers are not validated or standardised.
Shares Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue, Biomarkers are not validated or standardised.
Shares Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue, Biomarkers are not validated or standardised.
Shares Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue, Biomarkers are not validated or standardised.
Shares Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue, Biomarkers are not validated or standardised.
Shares Examination of Low ERBB2 Protein Expression in Breast Cancer Tissue, Biomarkers are not validated or standardised.