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Some everyday medicines, such as antibiotics or steroids, seem to blunt immunotherapy. Automatically scanning health records for such harmful pairs would catch them years earlier.
Antibiotics, proton-pump inhibitors and corticosteroids are associated with worse outcomes on checkpoint inhibitors in retrospective series, yet these signals took years to surface. A pharmacovigilance-style system that continuously screens clinico-genomic databases for concomitant medications associated with reduced efficacy (not just toxicity) would generate hypotheses for confirmation and, where confirmed, guideline warnings.
Shares Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy, Tempus AI, Too many combinations to test, Real-world evidence.
Shares Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy, Too many combinations to test, Real-world evidence, Weak real-world evidence and registries.
Shares Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy, Too many combinations to test, Real-world evidence, Weak real-world evidence and registries.
Shares Tempus AI, Real-world evidence, Weak real-world evidence and registries.
Shares Tempus AI, Real-world evidence, Weak real-world evidence and registries.
Shares Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy, Too many combinations to test, Real-world evidence.
Shares Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy, Too many combinations to test.
Shares Real-world evidence, Weak real-world evidence and registries.