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Patients join a long-term cohort once and agree in advance that they may be offered new treatments as they appear, while others in the cohort serve as the comparison group. No new trial has to start from zero.
The 'trials within cohorts' (TwiCs, or cohort multiple randomised controlled trial) design enrols a disease cohort with staged consent: patients agree to data collection and to being randomly selected for future interventions; those selected are offered the intervention, the rest continue standard care as controls. Utrecht's UMBRELLA breast cancer cohort has run several such trials. The idea is a cohort per major cancer in each large network.
Shares Trials enrol too few, too slowly, Trial design, endpoints and cost, Colorectal cancer.
Shares Trials enrol too few, too slowly, Trial design, endpoints and cost.
Shares Netherlands Cancer Institute (NKI-AvL), HR-positive / HER2-negative breast cancer, Colorectal cancer.
Shares Trials enrol too few, too slowly, Trial design, endpoints and cost.
Shares Netherlands Cancer Institute (NKI-AvL), Trials enrol too few, too slowly, Trial design, endpoints and cost.
Shares Trial design, endpoints and cost, HR-positive / HER2-negative breast cancer, Prostate cancer.
Shares Trials enrol too few, too slowly, Trial design, endpoints and cost.
Shares Trials enrol too few, too slowly, Trial design, endpoints and cost, Prostate cancer.