Loading
EBV infects almost everyone and causes nasopharyngeal cancer, some lymphomas and some stomach cancers. A vaccine given before infection could remove those cancers.
Epstein-Barr virus infects almost everyone and causes nasopharyngeal cancer, some lymphomas and some stomach cancers, so this idea accelerates development of an EBV vaccine given before infection, with infection prevention and infectious mononucleosis as first endpoints and later deployment in high-incidence nasopharyngeal cancer regions. Moderna's mRNA-1189 and the NIH gp350 nanoparticle vaccine are in early trials, and HPV and HBV vaccines prove that preventing a viral infection prevents its cancers. The test is a phase 2 infection-prevention trial in EBV-seronegative adolescents. At early-clinical maturity it addresses the bottleneck Prevention we already have is not deployed and links to head and neck cancer, Hodgkin lymphoma and gastric cancer.
One bottleneck page and 27 idea pages on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
The start of viral oncology. Everything in cancer prevention that works by preventing or treating an infection, from hepatitis B vaccination to Helicobacter eradication for gastric MALT lymphoma, descends from the idea this paper established.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed, Gastric & gastro-oesophageal junction cancer.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed, Gastric & gastro-oesophageal junction cancer.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed, Gastric & gastro-oesophageal junction cancer.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed, Head and neck squamous cell carcinoma.
Shares Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, Prevention we already have is not deployed.