Loading
Cisplatin causes permanent hearing loss. A cheap drug, sodium thiosulfate, protects children; test and roll it out for adults too.
Sodium thiosulfate is approved to reduce cisplatin ototoxicity in children with localised solid tumours after randomised trials. Adults with head and neck, testicular, lung and bladder cancers receive cisplatin in large numbers and commonly lose hearing, with no protective standard. The proposal is randomised trials of delayed sodium thiosulfate and other candidates (statins, transtympanic agents) in adult cisplatin regimens with audiometry and patient-reported hearing endpoints, with careful attention to tumour outcome non-inferiority.
Shares Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials, Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs, Toxicity and quality of life are undervalued, Platinum agents.
Shares Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials, Toxicity and quality of life are undervalued, Head and neck squamous cell carcinoma.
Shares Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials, Toxicity and quality of life are undervalued.
Shares Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials, Toxicity and quality of life are undervalued.
Shares Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials, Toxicity and quality of life are undervalued.
Shares Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials, Toxicity and quality of life are undervalued.
Shares Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials, Toxicity and quality of life are undervalued.
Shares Symptomatic toxicities experienced during anticancer treatment: agreement between patient and physician reporting in three randomized trials, Toxicity and quality of life are undervalued.