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When researchers use hospital records to ask 'would drug A have beaten drug B in a trial', they should follow a published recipe and register their plan first, so the answer can be trusted.
Target trial emulation (specifying the hypothetical randomised trial, then mimicking it in observational data) is the accepted framework for causal inference from real-world data, but the rigour of oncology emulations is inconsistent. The proposal is a formal standard: a protocol template (eligibility, treatment strategies, assignment, time zero, outcomes, causal contrast, analysis plan), mandatory pre-registration, and a requirement to report a positive control emulation of a known RCT in the same dataset, adopted by regulators and journals as a condition of considering RWE.
Shares Hazard ratio (HR), Real-world evidence, Weak real-world evidence and registries, Trial design, endpoints and cost.
Shares Real-world evidence, Weak real-world evidence and registries, Trial design, endpoints and cost.
Shares Real-world evidence, Weak real-world evidence and registries, Trial design, endpoints and cost.
Shares Real-world evidence, Weak real-world evidence and registries, Trial design, endpoints and cost.
Shares Real-world evidence, Weak real-world evidence and registries.
Shares Real-world evidence, Weak real-world evidence and registries.
Shares Real-world evidence, Weak real-world evidence and registries.
Shares Real-world evidence, Weak real-world evidence and registries.