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Hospitals rotate antibiotics to stop bacteria adapting. Cycling between two cancer drugs on a set schedule, rather than using one until it fails, might work the same way.
Antibiotic cycling and mixing are used to manage resistance in intensive care, with mathematical models predicting when each is superior. In oncology, drugs are almost always given until failure. Where two agents with non-overlapping resistance mechanisms and tolerable toxicity exist, scheduled rotation before resistance is established could keep both populations suppressed. Modelling should precede the trial to choose cycle length.
Shares RESTORE: bipolar androgen therapy after progression on enzalutamide in metastatic castration-resistant prostate cancer, Bipolar androgen therapy (BAT), Take high-dose testosterone to phase 3, with progression-free survival through the second line as the primary endpoint, Randomise the order of treatment, not only the drugs: a strategy platform for metastatic prostate cancer.
Shares Randomise the order of treatment, not only the drugs: a strategy platform for metastatic prostate cancer, Too many combinations to test, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Prostate cancer.
Shares Randomise the order of treatment, not only the drugs: a strategy platform for metastatic prostate cancer, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Acquired resistance to every therapy, Prostate cancer.
Shares RESTORE: bipolar androgen therapy after progression on enzalutamide in metastatic castration-resistant prostate cancer, Bipolar androgen therapy (BAT), Take high-dose testosterone to phase 3, with progression-free survival through the second line as the primary endpoint, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch.
Shares Take high-dose testosterone to phase 3, with progression-free survival through the second line as the primary endpoint, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Acquired resistance to every therapy, Prostate cancer.
Shares Intermittent androgen deprivation (IAD), Prostate cancer.
Shares Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer, Prostate cancer.
Shares Intermittent androgen deprivation (IAD), Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch, Prostate cancer.