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Trabedersen is an experimental investigational agent whose form is not stated in the registry from Oncotelic in phase 3 trials for pancreatic ductal adenocarcinoma, with its target not yet stated publicly.
Trabedersen (OT-101) is an investigational agent whose form is not stated in the registry developed by Oncotelic. The sponsor describes its target as TGF-beta2, which OnCo does not yet have a target page for. The sponsor states: An antisense oligodeoxynucleotide complementary to TGF-beta2 mRNA; by suppressing TGF-beta2, which cancers overexpress to cloak themselves from the immune system, it is intended to let innate or therapeutic immunity attack and eliminate the tumour. ClinicalTrials.gov describes the intervention as: OT-101: antisense oligodeoxynucleotide complementary to the messenger ribonucleic acid (mRNA) of the human TGF-β2 gene. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, including the phase 3 study NCT06079346 (A Study of OT-101 With mFOLFIRINOX in Patients With Advanced and Unresectable or Metastatic Pancreatic Cancer), in pancreatic ductal adenocarcinoma. The largest, NCT06079346, plans to enrol 455 participants with primary completion was scheduled for 2026-06-01 on the registry. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
An antisense oligodeoxynucleotide complementary to TGF-beta2 mRNA; by suppressing TGF-beta2, which cancers overexpress to cloak themselves from the immune system, it is intended to let innate or therapeutic immunity attack and eliminate the tumour.
1.Trabedersen slips into a pocket on its target.
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Query for this drug: (TITLE:"Trabedersen" OR ABSTRACT:"Trabedersen" OR TITLE:"OT-101" OR ABSTRACT:"OT-101") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Trabedersen, not a curated reading list.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.