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Foscan is a light-activated drug used in Europe to shrink advanced head and neck cancers that have failed other treatments and cannot be operated on, irradiated or given chemotherapy, to relieve symptoms.
Temoporfin was authorised by the European Commission in October 2001 for palliative treatment of advanced head and neck squamous cell carcinoma failing prior therapies and unsuitable for radiotherapy, surgery or systemic chemotherapy, on open-label phase 2 studies in which a proportion of patients achieved local tumour responses and symptom relief. It is a second-generation photosensitiser with a shorter photosensitivity period than porfimer sodium (Photofrin), the first-generation agent approved in the US for oesophageal and lung cancer, but patients must still avoid bright light for about two weeks. The FDA did not approve it. Pain at the treated site, local swelling and skin photosensitivity are the main adverse effects. Marketed by biolitec.
Ball-and-stick model from PubChem 2D record (no 3D conformer available). PubChem record
Chlorin photosensitiser that accumulates in tumour tissue and, on illumination with 652 nm laser light four days after injection, generates singlet oxygen that causes tumour necrosis and vascular shutdown.
1.Temoporfin slips into a pocket on its target.
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| Region | Year | Indication |
|---|---|---|
| EU | 2001 | Palliative treatment of advanced head and neck squamous cell carcinoma failing prior therapy and unsuitable for radiotherapy, surgery or chemotherapy |
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