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Endostar is Simcere's recombinant endostatin, approved in China in 2005 with chemotherapy for advanced non-small-cell lung cancer, one of the first angiogenesis inhibitors approved anywhere.
Recombinant human endostatin (Endostar) was developed in China and is marketed by Simcere in Nanjing. The NMPA (then the SFDA) approved it in September 2005 in combination with vinorelbine and cisplatin for advanced non-small-cell lung cancer, a year after bevacizumab's US approval. It remains widely used in China and is being tested with immunotherapy.
A recombinant form of endostatin, a fragment of collagen XVIII that stops the growth of new blood vessels a tumour needs.
1.Recombinant human endostatin slips into a pocket on its target.
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| Region | Year | Indication |
|---|---|---|
| CN | 2005 | Advanced non-small-cell lung cancer, with vinorelbine and cisplatin |
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Query for this drug: (TITLE:"Recombinant human endostatin" OR ABSTRACT:"Recombinant human endostatin" OR TITLE:"Endostar" OR ABSTRACT:"Endostar" OR TITLE:"rh-endostatin" OR ABSTRACT:"rh-endostatin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Recombinant human endostatin, not a curated reading list.
Shares Systemic Chemotherapy Combined With Recombinant Human Adenovirus Type 5 and Endostatin Injections for Treatment Malignant Hydrothorax in NSCLC Patients and the tags china, nmpa-approved.
Shares Non-small-cell lung cancer and the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.