Loading
Patidegib is a hedgehog-pathway blocker made into a skin gel. It is being tested in people with Gorlin syndrome, who grow dozens of basal cell carcinomas, to prevent new tumours without the hair loss, muscle cramps and taste loss that the oral drugs cause.
Patidegib is the topical formulation of saridegib (IPI-926), a Smoothened inhibitor first developed by Infinity Pharmaceuticals as an oral drug. PellePharm reformulated it as a 2 percent gel applied twice daily to the face. Because Gorlin (basal cell nevus) syndrome is caused by germline PTCH1 loss, every basal cell carcinoma depends on hedgehog signalling, and oral vismodegib prevents them but is poorly tolerated for long-term use.
A phase 2 study in Gorlin syndrome reported fewer new surgically eligible basal cell carcinomas with the gel than with vehicle, and a phase 3 trial followed. It is named on the locally advanced basal cell carcinoma page as the prevention approach for patients with the syndrome.
A cyclopamine derivative that binds Smoothened and blocks hedgehog signalling in the skin; applied as a gel it reaches the basal cells where basal cell carcinomas start without the systemic side effects of oral hedgehog inhibitors. Connects to Smoothened (hedgehog pathway).
1.Patidegib slips into a pocket on Smoothened (hedgehog pathway).
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"Patidegib" OR ABSTRACT:"Patidegib" OR TITLE:"Saridegib topical" OR ABSTRACT:"Saridegib topical" OR TITLE:"IPI-926" OR ABSTRACT:"IPI-926") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Patidegib, not a curated reading list.
Shares Skin cancer (all types) and the tag subtype-drugs-wave.
Shares Efficacy and Safety of Patidegib Gel 2% for Preventing Basal Cell Carcinomas on the Face of Adults With Gorlin Syndrome, Patidegib gel in Gorlin syndrome (phase 2A), Why people stop taking hedgehog inhibitors, Smoothened (hedgehog pathway).
Shares PTCH1 (Patched 1), Patidegib gel in Gorlin syndrome (phase 2A), Sonidegib, Why people stop taking hedgehog inhibitors.
Shares Patidegib gel in Gorlin syndrome (phase 2A), Why people stop taking hedgehog inhibitors, Smoothened (hedgehog pathway), Vismodegib.
Shares Why people stop taking hedgehog inhibitors, Smoothened (hedgehog pathway), Vismodegib, Locally advanced and metastatic basal cell carcinoma.
Shares PTCH1 (Patched 1), Sonidegib, Smoothened (hedgehog pathway), Vismodegib.
Shares Sonidegib, Why people stop taking hedgehog inhibitors, Smoothened (hedgehog pathway), Locally advanced and metastatic basal cell carcinoma.
Shares PTCH1 (Patched 1), Patidegib gel in Gorlin syndrome (phase 2A), Why people stop taking hedgehog inhibitors, Locally advanced and metastatic basal cell carcinoma.