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E-EDV-D682 is an experimental EDV nanocell (bacterial minicell) drug conjugate from Engeneic Pty in phase 2 trials for pancreatic ductal adenocarcinoma, aimed at EGFR.
E-EDV-D682 (EDV-D682) is an EDV nanocell (bacterial minicell) drug conjugate developed by Engeneic Pty. Its target is EGFR (the sponsor names EGFR). The sponsor states: E-EDV-D682 packages the chemotherapeutic payload PNU-159682 inside a 400 nm, bacterially derived EnGeneIC EDV nanocell that is targeted to EGFR-expressing cancer cells via a bispecific antibody, delivering the payload directly into tumour cells. ClinicalTrials.gov describes the intervention as: E-EDV-D682 is a product based on the EnGeneIC EDV™ technology. EDVs are bacterially derived nanocells 400 nm in diameter that can be packaged with a range of different chemotherapeutic drugs and specifically targeted to cancer cell receptor. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, in pancreatic ductal adenocarcinoma. The largest, NCT07049055, plans to enrol 144 participants with primary completion expected 2028-09. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
E-EDV-D682 packages the chemotherapeutic payload PNU-159682 inside a 400 nm, bacterially derived EnGeneIC EDV nanocell that is targeted to EGFR-expressing cancer cells via a bispecific antibody, delivering the payload directly into tumour cells. Connects to EGFR.
1.E-EDV-D682's antibody arm binds EGFR on the surface of the cancer cell.
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Query for this drug: (TITLE:"E-EDV-D682" OR ABSTRACT:"E-EDV-D682" OR TITLE:"EDV-D682" OR ABSTRACT:"EDV-D682") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about E-EDV-D682, not a curated reading list.
Shares EGFR and the tag pipeline.
Shares EGFR and the tag pipeline.
Shares EGFR and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares EGFR and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma and the tag pipeline.