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DZD8586 is an experimental small-molecule drug from Dizal Pharmaceuticals in phase 3 trials for chronic lymphocytic leukaemia and diffuse large B-cell lymphoma, with its target not yet stated publicly.
DZD8586 is a small-molecule drug developed by Dizal Pharmaceuticals. Its molecular target is not stated in the ClinicalTrials.gov intervention record, and OnCo has not confirmed one from the sponsor's pipeline page. It is the investigational product in 4 recruiting or active industry-led phase 2 and phase 3 interventional cancer trials, including the phase 3 study NCT07139873 (A Study of DZD8586 Versus Investigator's Choice in r/r CLL/SLL (TAI-SHAN6)), in chronic lymphocytic leukaemia and diffuse large B-cell lymphoma. The largest, NCT07139873, plans to enrol 250 participants with primary completion expected 2029-01. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
Mechanism not stated in the ClinicalTrials.gov record or on the sponsor's pipeline page.
1.DZD8586 slips into a pocket on its target.
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Query for this drug: (TITLE:"DZD8586" OR ABSTRACT:"DZD8586" OR TITLE:"Birelentinib" OR ABSTRACT:"Birelentinib") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DZD8586, not a curated reading list.
Shares Chronic lymphocytic leukaemia, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Dizal Pharmaceutical and the tag pipeline.
Shares Dizal Pharmaceutical and the tag pipeline.
Shares Chronic lymphocytic leukaemia, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Chronic lymphocytic leukaemia, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Dizal Pharmaceutical and the tag pipeline.
Shares Chronic lymphocytic leukaemia, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Chronic lymphocytic leukaemia, Diffuse large B-cell lymphoma and the tag pipeline.