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Darovasertib is an experimental small-molecule drug from IDEAYA Biosciences in phase 3 trials for uveal melanoma and melanoma, with its target not yet stated publicly.
Darovasertib (IDE196, LXS196) is a small-molecule drug developed by IDEAYA Biosciences. The sponsor describes its target as PKC (protein kinase C), which OnCo does not yet have a target page for. The sponsor states: Darovasertib is a small-molecule PKC inhibitor targeting the oncogenic driver of uveal melanoma associated with GNAQ/GNA11 mutations or PRKC fusions. It is the investigational product in 3 recruiting or active industry-led phase 2 and phase 3 interventional cancer trials, including phase 3 studies NCT07804186 (Study of Adjuvant Darovasertib and Crizotinib in Participants With Primary Non-metastatic Uveal Melanoma) and NCT07015190 (Neoadjuvant Darovasertib in Primary Uveal Melanoma), in uveal melanoma and melanoma. The largest, NCT07015190, plans to enrol 520 participants with primary completion expected 2030-10. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
Darovasertib is a small-molecule PKC inhibitor targeting the oncogenic driver of uveal melanoma associated with GNAQ/GNA11 mutations or PRKC fusions.
1.Darovasertib slips into a pocket on its target.
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Query for this drug: (TITLE:"Darovasertib" OR ABSTRACT:"Darovasertib" OR TITLE:"IDE196" OR ABSTRACT:"IDE196" OR TITLE:"LXS196" OR ABSTRACT:"LXS196" OR TITLE:"IDE 196" OR ABSTRACT:"IDE 196") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Darovasertib, not a curated reading list.
Shares GNAQ, Uveal melanoma and the tag pipeline.
Shares Uveal melanoma, Melanoma and the tag pipeline.
Shares IDEAYA Biosciences and the tag pipeline.
Shares Uveal melanoma and the tag pipeline.
Shares Uveal melanoma and the tag pipeline.
Shares Uveal melanoma and the tag pipeline.
Shares Uveal melanoma and the tag pipeline.
Shares Uveal melanoma and the tag pipeline.