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Chlorambucil (Leukeran) is a gentle oral chemotherapy tablet used for decades in chronic lymphocytic leukaemia and low-grade lymphomas, mainly in older patients.
Approved in 1957, chlorambucil is indicated for chronic lymphocytic leukaemia and malignant lymphomas including lymphosarcoma, giant follicular lymphoma and Hodgkin disease; the label states it is palliative rather than curative. It was the comparator arm in the trials that established fludarabine, alemtuzumab and, with obinutuzumab (CLL11), the chemoimmunotherapy era in unfit CLL patients, and it is still used with an anti-CD20 antibody in frail patients where BTK inhibitors or venetoclax are unavailable. Myelosuppression is dose-limiting; long-term use increases the risk of secondary leukaemia and it is teratogenic and impairs fertility.
Aromatic nitrogen mustard that alkylates DNA, interfering with replication and inducing p53- and Bax-mediated apoptosis.
1.Chlorambucil slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1957 | Chronic lymphocytic leukaemia; Hodgkin and non-Hodgkin lymphomas (palliative) |
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Query for this drug: (TITLE:"Chlorambucil" OR ABSTRACT:"Chlorambucil" OR TITLE:"Leukeran" OR ABSTRACT:"Leukeran") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Chlorambucil, not a curated reading list.
Shares A Study of BGB-16673 Compared to Investigator's Choice in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Covalent Bruton Tyrosine Kinase (BTK) Inhibitors, Chronic lymphocytic leukaemia, first treatment, Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), Marginal zone lymphoma and the tag generic.
Shares Phosphorus-32 (radiophosphorus), Cytotoxic chemotherapy and the tag generic.
Shares Hodgkin lymphoma, Cytotoxic chemotherapy and the tag generic.
Shares Chronic lymphocytic leukaemia, first treatment, Chronic lymphocytic leukaemia, Cytotoxic chemotherapy and the tag generic.
Shares Hodgkin lymphoma, Cytotoxic chemotherapy and the tag generic.
Shares Cytotoxic chemotherapy and the tag generic.
Shares Cytotoxic chemotherapy and the tag generic.
Shares Cytotoxic chemotherapy and the tag generic.