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Brenetafusp is a soluble T-cell receptor bispecific, tebentafusp's successor, that recognises a PRAME peptide on HLA-A*02:01 and drags T cells onto the tumour. A phase 3 with nivolumab in first-line melanoma is enrolling, but only patients carrying HLA-A*02:01, about half of those of European ancestry, are eligible.
Phase 1/2 in heavily pretreated cutaneous melanoma: median OS 14.3 months on monotherapy (ASCO 2026 update). PRISM-MEL-301 phase 3 with nivolumab in first-line HLA-A*02:01-positive melanoma is enrolling; further trials in ovarian, lung, and endometrial cancer. Requires HLA-A*02:01 (roughly half of European-ancestry patients).
1.The TCR arm binds PRAME peptide displayed on HLA-A*02:01 on the tumour cell
Source: clinicaltrials.gov/study/NCT06112314. Doses are for orientation; the current label governs.
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Phase 3 PRISM-MEL-301 initiated after FDA alignment on design
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Query for this drug: (TITLE:"Brenetafusp" OR ABSTRACT:"Brenetafusp" OR TITLE:"IMC-F106C" OR ABSTRACT:"IMC-F106C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Brenetafusp, not a curated reading list.
Shares Uveal melanoma prognostic markers (GNAQ/GNA11, monosomy 3, gene-expression class), HLA-A*02:01 restriction, HLA-A, Tebentafusp.
Shares Immunocore, Tebentafusp, Advanced melanoma (unresectable stage III and stage IV), T-cell engagers (bispecific).
Shares Tebentafusp, CD3, Uveal melanoma, T-cell engagers (bispecific).
Shares HLA-A, Tebentafusp, Uveal melanoma, T-cell engagers (bispecific).
Shares Immunocore, Tebentafusp, CD3, T-cell engagers (bispecific).
Shares Tebentafusp, Uveal melanoma, T-cell engagers (bispecific), Melanoma.
Shares PRAME, Advanced melanoma (unresectable stage III and stage IV), Melanoma.
Shares Uveal melanoma, Advanced melanoma (unresectable stage III and stage IV), Melanoma.