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A next-generation pill that blocks only CDK4, not CDK6, to keep the benefit of today's drugs without the low blood counts.
Pfizer's CDK4-selective inhibitor. Phase 2 FOURLIGHT-1 (second line, with fulvestrant) positive in early 2026 with lower neutropenia than dual inhibitors; phase 3 FOURLIGHT-3 compares atirmociclib + letrozole with a CDK4/6 inhibitor + letrozole in first line. Rationale: CDK6 inhibition drives neutropenia while CDK4 carries most of the antitumour effect in luminal breast cancer.
ATP-competitive inhibitor selective for CDK4 over CDK6 (~70-fold). Connects to CDK4/6.
1.Cyclin D1-CDK4 phosphorylates RB in luminal breast cancer cells
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Positive topline phase 2 FOURLIGHT-1 source
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Query for this drug: (TITLE:"Atirmociclib" OR ABSTRACT:"Atirmociclib" OR TITLE:"PF-07220060" OR ABSTRACT:"PF-07220060") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Atirmociclib, not a curated reading list.
Shares HR-positive metastatic breast cancer after CDK4/6 inhibitors, CDK4/6, Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test, CDK4/6 inhibitors.
Shares A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer., Study of PF-07248144 in Advanced or Metastatic Solid Tumors, HR-positive metastatic breast cancer after CDK4/6 inhibitors, Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test.
Shares CDK4/6, Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test, CDK4/6 inhibitors, Pfizer (incl. Seagen).
Shares CDK4/6, Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test, CDK4/6 inhibitors, HR-positive / HER2-negative breast cancer.
Shares Study of PF-07248144 in Advanced or Metastatic Solid Tumors, Pfizer (incl. Seagen), HR-positive / HER2-negative breast cancer.
Shares CDK4/6, Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test, CDK4/6 inhibitors, HR-positive / HER2-negative breast cancer.
Shares The cell-cycle engine (cyclins & CDKs), CDK4/6, CDK4/6 inhibitors.
Shares CDK4/6, Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test, CDK4/6 inhibitors, HR-positive / HER2-negative breast cancer.