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Abexinostat is an experimental small-molecule drug from Xynomic Pharmaceuticals in phase 3 trials for renal cell carcinoma, diffuse large B-cell lymphoma and follicular lymphoma, with its target not yet stated publicly.
Abexinostat (PCI-24781) is a small-molecule drug developed by Xynomic Pharmaceuticals. Its molecular target is not stated in the ClinicalTrials.gov intervention record, and OnCo has not confirmed one from the sponsor's pipeline page. ClinicalTrials.gov describes the intervention as: Abexinostat tosylate salt is formulated into an oral tablet formulation and is available in 20 mg strength. It is the investigational product in 5 recruiting or active industry-led phase 2 and phase 3 interventional cancer trials, including the phase 3 study NCT03592472 (A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)), in renal cell carcinoma, diffuse large B-cell lymphoma, follicular lymphoma and hodgkin lymphoma. The largest, NCT03592472, plans to enrol 413 participants with primary completion expected 2026-12-30. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
Mechanism not stated in the ClinicalTrials.gov record or on the sponsor's pipeline page.
1.Abexinostat slips into a pocket on its target.
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Query for this drug: (TITLE:"Abexinostat" OR ABSTRACT:"Abexinostat" OR TITLE:"PCI-24781" OR ABSTRACT:"PCI-24781") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Abexinostat, not a curated reading list.
Shares Follicular lymphoma, Hodgkin lymphoma, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Follicular lymphoma, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Hodgkin lymphoma, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Follicular lymphoma, Hodgkin lymphoma, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Follicular lymphoma, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Follicular lymphoma, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Follicular lymphoma, Diffuse large B-cell lymphoma and the tag pipeline.
Shares Follicular lymphoma, Diffuse large B-cell lymphoma and the tag pipeline.