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Xanthine oxidase makes uric acid from the breakdown of DNA; allopurinol blocks it to prevent the kidney damage of tumour lysis syndrome when chemotherapy kills many cancer cells at once. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
A molybdenum-containing enzyme of purine catabolism in liver and gut; its oxidase form also generates reactive oxygen species.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Metastatic cancer | host% | Host target: xanthine oxidase in uric acid formation. Not a tumour alteration, so no prevalence applies; the drug acts on normal tissue or on symptoms. |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"Xanthine oxidase" OR ABSTRACT:"Xanthine oxidase" OR TITLE:"XDH" OR ABSTRACT:"XDH") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Xanthine oxidase (XDH), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/xdh.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/xdh.json. Licence CC BY-NC 4.0.