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Tissue factor is a clotting protein that cancers abnormally display on their surface, used as an ADC target in cervical cancer. This dossier gathers the 1 product (1 approved), 3 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Initiates the extrinsic coagulation cascade; tumour expression drives thrombosis and angiogenesis.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Cervical cancer | 90-95% | IHC, any expression | innovaTV did not select on TF | Wikipedia |
| Pancreatic ductal adenocarcinoma | 50-80% | IHC, any expression | Wikipedia |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
| Modality | Approved |
|---|---|
| ADC 1 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
innovaTV 301 / ENGOT-cx12 / GOG-3057 NCT04697628 | 3 | Positive | Recurrent or metastatic cervical cancer after 1-2 prior lines including platinum: tisotumab vedotin vs investigator's-choice chemotherapy | OS 11.5 vs 9.5 months (HR 0.70). | |
| 3 | Active | A Phase 3 Randomized, Active-controlled, Open-label, Multicenter Study to Compare the Efficacy and Safety of MK-2870 Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (TroFuse-020/GOG-3101/ENGOT-cx20) | - | ||
| 2 | Active | Open Label Phase 2 Study of Tisotumab Vedotin for Locally Advanced or Metastatic Disease in Solid Tumors | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"Tissue factor" OR ABSTRACT:"Tissue factor" OR TITLE:"F3" OR ABSTRACT:"F3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Tissue factor, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/tissue-factor.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/tissue-factor.json. Licence CC BY-NC 4.0.