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RNF43 (E3 ubiquitin-protein ligase RNF43) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Colorectal cancer, Gastric & gastro-oesophageal junction cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signalling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signalling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification. Location: Cell membrane; Endoplasmic reticulum membrane; Nucleus envelope (UniProt). Locus 17q22 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Colorectal cancer | 5-12% | Inactivating mutation (G659fs hotspot) | cBioPortal: 734 of 7,237, 10.1%, in crc_msk_2026; 95 of 1,134, 8.4%, in crc_msk_2017; 105 of 1,516, 6.9%, in crc_eo_2020; 46 of 534, 8.6%, in coadread_tcga_pan_can_atlas_2018; 72 of 619, 11.6%, in coadread_dfci_2016. | cBioPortal (TCGA) |
| Pancreatic ductal adenocarcinoma | 5-8% | Inactivating mutation | cBioPortal: 142 of 2,336, 6.1%, in pdac_msk_2024; 30 of 395, 7.6%, in pancreas_msk_2024; 11 of 179, 6.1%, in paad_tcga_pan_can_atlas_2018; 21 of 383, 5.5%, in paad_qcmg_uq_2016; 9 of 140, 6.4%, in paad_cptac_2021; 6 of 109 in paad_utsw_2015. Mutated in 6 of 8 IPMNs and 3 of 8 MCNs, establishing it as a suppressor of both (Wu 2011, PNAS); RNF43 alterations were largely confined to the non-invasive lesions in cyst progression (Noe 2020); a recurrent gene in TCGA (Cancer Genome Atlas 2017) and part of the WNT pathway of the ten (Bailey 2016). | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"RNF43" OR ABSTRACT:"RNF43" OR TITLE:"ring finger protein 43" OR ABSTRACT:"ring finger protein 43" OR TITLE:"E3 ubiquitin-protein ligase RNF43" OR ABSTRACT:"E3 ubiquitin-protein ligase RNF43" OR TITLE:"FLJ20315" OR ABSTRACT:"FLJ20315" OR TITLE:"RNF124" OR ABSTRACT:"RNF124" OR TITLE:"DKFZp781H0392" OR ABSTRACT:"DKFZp781H0392") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RNF43, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/rnf43.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/rnf43.json. Licence CC BY-NC 4.0.