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RAC1 (Ras-related C3 botulinum toxin substrate 1) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Head and neck squamous cell carcinoma and Melanoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarisation, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Location: Cell membrane; Melanosome; Cytoplasm; Cell projection, lamellipodium (UniProt). Locus 7p22.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"RAC1" OR ABSTRACT:"RAC1" OR TITLE:"Rac family small GTPase 1" OR ABSTRACT:"Rac family small GTPase 1" OR TITLE:"Ras-related C3 botulinum toxin substrate 1" OR ABSTRACT:"Ras-related C3 botulinum toxin substrate 1" OR TITLE:"TC-25" OR ABSTRACT:"TC-25" OR TITLE:"p21-Rac1" OR ABSTRACT:"p21-Rac1" OR TITLE:"Rac-1" OR ABSTRACT:"Rac-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAC1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/rac1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/rac1.json. Licence CC BY-NC 4.0.