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MGMT is a DNA repair enzyme that removes the damage temozolomide causes; when the gene is switched off by methylation the tumour cannot repair itself and the drug works better. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Loss of MGMT leaves O6-methylguanine unrepaired, which mispairs with thymine and triggers mismatch-repair-driven cell death; tumours that lose mismatch repair as well become hypermutated and resistant.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"MGMT" OR ABSTRACT:"MGMT" OR TITLE:"O6-methylguanine-DNA methyltransferase" OR ABSTRACT:"O6-methylguanine-DNA methyltransferase" OR TITLE:"O-6-methylguanine-DNA methyltransferase" OR ABSTRACT:"O-6-methylguanine-DNA methyltransferase" OR TITLE:"AGT" OR ABSTRACT:"AGT" OR TITLE:"O6-alkylguanine DNA alkyltransferase" OR ABSTRACT:"O6-alkylguanine DNA alkyltransferase") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MGMT (O6-methylguanine-DNA methyltransferase), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/mgmt-protein.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/mgmt-protein.json. Licence CC BY-NC 4.0.