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GREM1 (Gremlin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer. This dossier gathers the 1 product (0 approved), 1 trial, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signalling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. Location: Secreted (UniProt). Locus 15q13.3 (HGNC).
| Modality | Phase 2 |
|---|---|
| Antibody 1 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
| 1/2 | Active | A First-in-Human, Open-Label, Multi-Center Phase 1 Study of TST003 in Subjects With Locally Advanced or Metastatic Solid Tumors | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"GREM1" OR ABSTRACT:"GREM1" OR TITLE:"gremlin 1, DAN family BMP antagonist" OR ABSTRACT:"gremlin 1, DAN family BMP antagonist" OR TITLE:"Gremlin-1" OR ABSTRACT:"Gremlin-1" OR TITLE:"gremlin" OR ABSTRACT:"gremlin" OR TITLE:"DAND2" OR ABSTRACT:"DAND2" OR TITLE:"CKTSF1B1" OR ABSTRACT:"CKTSF1B1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GREM1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/grem1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/grem1.json. Licence CC BY-NC 4.0.