{"id":"grem1","name":"GREM1","symbol":"GREM1","route":"/targets/grem1/","asOf":"2026-09-23","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2001","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166923","uniprot":"https://www.uniprot.org/uniprotkb/O60565/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/O60565","open-targets":"https://platform.opentargets.org/target/ENSG00000166923","civic":"https://civicdb.org/genes/26585/summary","oncokb":"https://www.oncokb.org/gene/GREM1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=GREM1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=GREM1","depmap":"https://depmap.org/portal/gene/GREM1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000166923-GREM1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/26585","omim":"https://www.omim.org/entry/603054"}],"products":[{"id":"tst003","name":"TST003","status":"phase-2","modality":"Monoclonal antibody","route":"/drugs/tst003/"}],"trials":[{"id":"nct05731271","name":"A First-in-Human, Phase 1 Study of TST003 in Subjects With Solid Tumors","nct":"NCT05731271","phase":"1/2","status":"active"}],"pathways":[],"companies":["transcenta"],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}