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FCGR2B (Low affinity immunoglobulin gamma Fc region receptor II-b) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Non-Hodgkin lymphoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. Location: Cell membrane (UniProt). Locus 1q23.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"FCGR2B" OR ABSTRACT:"FCGR2B" OR TITLE:"Fc gamma receptor IIb" OR ABSTRACT:"Fc gamma receptor IIb" OR TITLE:"Low affinity immunoglobulin gamma Fc region receptor II-b" OR ABSTRACT:"Low affinity immunoglobulin gamma Fc region receptor II-b" OR TITLE:"CD32" OR ABSTRACT:"CD32" OR TITLE:"CD32B" OR ABSTRACT:"CD32B" OR TITLE:"FcgammaRIIb" OR ABSTRACT:"FcgammaRIIb") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FCGR2B, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/fcgr2b.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/fcgr2b.json. Licence CC BY-NC 4.0.