{"entity":{"id":"fcgr2b","kind":"target","name":"FCGR2B","aka":["Fc gamma receptor IIb","Low affinity immunoglobulin gamma Fc region receptor II-b","CD32","CD32B","FcgammaRIIb","FcGRIIB","FCG2","FCGR2"],"tldr":"FCGR2B (Low affinity immunoglobulin gamma Fc region receptor II-b) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Non-Hodgkin lymphoma.","summary":"Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.95, animal model 0.42, genetic association 0.36, somatic mutation 0.95). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Malignant Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3618","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3618"},{"label":"UniProt P31994","url":"https://www.uniprot.org/uniprotkb/P31994/entry"},{"label":"NCBI Gene 2213","url":"https://www.ncbi.nlm.nih.gov/gene/2213"},{"label":"Ensembl ENSG00000072694","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000072694"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["breast-cancer","non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FCGR2B","role":["tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3618","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3618","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31994","url":"https://www.uniprot.org/uniprotkb/P31994/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FCGR2B","url":"https://civicdb.org/features/1843","note":"1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000072694","url":"https://platform.opentargets.org/target/ENSG00000072694/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: breast cancer 0.50 (GraphQL API, CC0)"},{"label":"IntOGen FCGR2B","url":"https://www.intogen.org/search?gene=FCGR2B","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"few-types","specificityNote":"Tumour-specific alteration: the catalogues call it a tumour suppressor (IntOGen finds it knocked out more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA FCGR2B: RNA tissue enriched (placenta 378 nTPM); high antibody staining in 1 normal tissue. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P31994","url":"https://www.uniprot.org/uniprotkb/P31994/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FCGR2B","url":"https://civicdb.org/features/1843","note":"1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"},{"label":"IntOGen FCGR2B","url":"https://www.intogen.org/search?gene=FCGR2B","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas FCGR2B tissue","url":"https://www.proteinatlas.org/ENSG00000072694-FCGR2B/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000072694 associations","url":"https://platform.opentargets.org/target/ENSG00000072694/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3618","ensembl":"ENSG00000072694","uniprot":"P31994","entrez":"2213","firstDescribed":1989,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Stuart S.G. et al, EMBO J, 1989, \"Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2531080/","biology":"Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. Location: Cell membrane (UniProt). Locus 1q23.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.50 with breast cancer (MONDO_0007254); CIViC evidence names this disease","Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (MLYM)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/fcgr2b/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}