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ESR2 (Oestrogen receptor beta) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Breast cancer and Prostate cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Nuclear hormone receptor. Binds oestrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing oestrogen response elements (ERE) in an oestrogen-dependent manner. Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. Location: Nucleus (UniProt). Locus 14q23.2-q23.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ESR2" OR ABSTRACT:"ESR2" OR TITLE:"estrogen receptor 2" OR ABSTRACT:"estrogen receptor 2" OR TITLE:"Estrogen receptor beta" OR ABSTRACT:"Estrogen receptor beta" OR TITLE:"NR3A2" OR ABSTRACT:"NR3A2" OR TITLE:"Erb" OR ABSTRACT:"Erb" OR TITLE:"ER-beta" OR ABSTRACT:"ER-beta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ESR2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/esr2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/esr2.json. Licence CC BY-NC 4.0.