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CYP11A1 is the first enzyme in making every steroid hormone from cholesterol; the historic breast cancer drug aminoglutethimide blocked it, cutting oestrogen and adrenal steroids, before aromatase inhibitors made that approach precise. This dossier gathers the 1 product (0 approved), 1 trial, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
A mitochondrial cytochrome P450 of adrenal cortex, gonads and placenta; it requires adrenodoxin and adrenodoxin reductase to receive electrons from NADPH.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| HR-positive / HER2-negative breast cancer | host% | Host target: first enzyme of steroid synthesis. Not a tumour alteration, so no prevalence applies; the drug acts on normal tissue or on symptoms. |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
| Modality | Withdrawn or failed |
|---|---|
| Small molecule 1 |
| Trial | Status | Setting | Result | Products | |
|---|---|---|---|---|---|
| 2 | - | A Phase II Trial of Early Medical Adrenalectomy for "D0.5" Prostate Cancer | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"CYP11A1" OR ABSTRACT:"CYP11A1" OR TITLE:"cholesterol side-chain cleavage enzyme" OR ABSTRACT:"cholesterol side-chain cleavage enzyme") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CYP11A1 (cholesterol side-chain cleavage enzyme), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/cyp11a1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cyp11a1.json. Licence CC BY-NC 4.0.