{"id":"cyp11a1","name":"CYP11A1 (cholesterol side-chain cleavage enzyme)","symbol":"CYP11A1","route":"/targets/cyp11a1/","asOf":"2026-09-04","xrefs":[{"hgnc":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2590","ensembl":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140459","uniprot":"https://www.uniprot.org/uniprotkb/P05108/entry","alphafold-db":"https://alphafold.ebi.ac.uk/entry/P05108","chembl":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2033","open-targets":"https://platform.opentargets.org/target/ENSG00000140459","civic":"https://civicdb.org/genes/1583/summary","oncokb":"https://www.oncokb.org/gene/CYP11A1","cosmic":"https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=CYP11A1","cbioportal":"https://www.cbioportal.org/results/mutations?cancer_study_list=msk_impact_2017&gene_list=CYP11A1","depmap":"https://depmap.org/portal/gene/CYP11A1?tab=overview","human-protein-atlas":"https://www.proteinatlas.org/ENSG00000140459-CYP11A1","ncbi-gene":"https://www.ncbi.nlm.nih.gov/gene/1583","omim":"https://www.omim.org/entry/118485"}],"products":[{"id":"aminoglutethimide","name":"Aminoglutethimide","status":"historic","modality":"Oral steroidogenesis inhibitor","route":"/drugs/aminoglutethimide/"}],"trials":[{"id":"nct00006371","name":"A Phase II Trial of Early Medical Adrenalectomy for \"D0.5\" Prostate Cancer","nct":"NCT00006371","phase":"2"}],"pathways":[],"companies":[],"keyPapers":[],"hotspots":[],"openQuestions":[],"assays":[],"resistance":[],"licence":"CC BY-NC 4.0, attribution to OnCo (https://onco.cc); commercial use needs a licence"}