Valius Sciences

Valius Sciences, based in Silicon Valley, is a patient-centred multi-omic profiling service that runs whole genome sequencing, bulk and single-cell RNA sequencing, spatial transcriptomics, high-plex protein assays and circulating tumour DNA testing on a single tumour. It combines validated assays across DNA, RNA and protein layers with functional drug screening to surface actionable targets for ADCs, bispecifics and CAR-T that standard panels miss, is backed by Define Ventures and is positioned as a premium service for complex or rare cancers. OnCo links it to whole-genome sequencing, single-cell and spatial profiling, liquid biopsy, functional ex vivo drug testing and comprehensive genomic profiling. Whether deep profiling changes treatment often enough to justify its cost is the open question. The related technology pages carry the evidence.