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Theolytics is an Oxford biotech that screens huge libraries of adenoviruses to find ones that kill particular cancers; THEO-260 is its lead for ovarian cancer.
Theolytics, spun out of the University of Oxford, uses directed evolution and high-throughput screening of adenovirus libraries to select oncolytic viruses with the best tumour selectivity and potency for a chosen cancer. THEO-260, selected against ovarian cancer cells, entered a phase 1/2 trial in platinum-resistant ovarian cancer in 2024 and is also being developed for intravenous delivery.
THEO-260 is an oncolytic virus from Theolytics Limited, in registered phase 2 trials for ovarian cancer.