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Telik
Telik was a Palo Alto biotech whose glutathione analogue canfosfamide (Telcyta) failed its phase 3 trials in ovarian and lung cancer in the 2000s, a reminder that late-stage failure is the norm in oncology.
Also called: Telik, Inc.
Overview
Telik, Inc., founded in 1988 in Palo Alto, California, developed canfosfamide (TLK286, Telcyta), a prodrug activated by glutathione S-transferase P1-1 that is overexpressed in many tumours. It led phase 3 trials in platinum-resistant ovarian cancer and non-small cell lung cancer, none of which met their primary endpoints, and the company later wound down its programmes. Its trials remain on ClinicalTrials.gov under Telik as lead sponsor.
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