Nobelpharma is a Tokyo company founded in 2003 to develop medicines for rare diseases and unmet needs in Japan, including cancer treatments it takes through phase 3 trials.
Nobelpharma Co., Ltd., based in Chūō, Tokyo, was founded in 2003 to bring medicines for rare diseases and unmet medical needs to the Japanese market, often licensing products approved elsewhere and running the Japanese trials needed for approval. It is lead sponsor of several phase 3 cancer trials registered on ClinicalTrials.gov. Its product list includes two cancer medicines: Cosmegen (dactinomycin) for Wilms tumour, choriocarcinoma and paediatric solid tumours, and Zanosar (streptozocin) for gastroenteropancreatic neuroendocrine tumours, alongside Unitalc (talc) for malignant pleural effusion.
The first antibiotic used as an anticancer drug (1954) and still the core of chemotherapy for Wilms tumour, rhabdomyosarcoma and gestational trophoblastic disease.
Streptozocin is a chemotherapy drug that seeks out pancreatic islet cells, approved in 1982 for the rare tumours that arise from them; the same selectivity makes it the standard way to induce diabetes in laboratory animals.